Lee F Eun-Hyung, Walsh Edward E, Falsey Ann R, Liu Nathaniel, Liu Dacheng, Divekar Anagha, Snyder-Cappione Jennifer E, Mosmann Tim R
David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA.
Mech Ageing Dev. 2005 Nov;126(11):1223-9. doi: 10.1016/j.mad.2005.06.011.
Respiratory syncytial virus (RSV) and influenza virus cause severe disease in elderly patients. The balance of pro- and anti-inflammatory cytokines may be critical in determining disease pathogenesis and outcome of infection. The frequencies of CD4 IL-10 (anti-inflammatory)- and CD4 and CD8 IFNgamma (pro-inflammatory)-secreting memory T cells specific for either RSV or influenza were not significantly different between young and elderly groups, although the ratio of IL-10/IFNgamma was significantly reduced in the elderly RSV response. A similar trend was seen for influenza. IFNgamma-secreting CD4 T cells contributed significantly more to anti-RSV than anti-influenza responses in both groups.
