Miyazawa Nobuhiko, Arbab Ali Syed, Umeda Takako, Akiyama Iwao
Department of Neurosurgery, Akiyama Neurosurgical Clinic, Nirasaki, Yamanashi, Japan.
Clin Neurol Neurosurg. 2005 Dec;108(1):11-7. doi: 10.1016/j.clineuro.2004.12.024. Epub 2005 Aug 10.
This study investigated the usefulness of perfusion computed tomography (CT) for the evaluation of patients with chronic internal carotid artery (ICA) occlusion by comparing the findings with those of iodine-123 iodoamphetamine ([(123)I]IMP) single photon emission computed tomography (SPECT). Twenty five patients with chronic ICA occlusion were investigated on the same day by perfusion CT to measure the cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transient time (MTT), and [(123)I]IMP SPECT to measure the regional CBF, significant correlations were observed between regional CBF measured by SPECT and CBF measured by perfusion CT (r = 0.659, R(2) = 0.434, p < 0.001), regional CBF and CBV (r = -0.406, R(2) = 0.165, p < 0.001) and regional CBF and MTT (r = -0.592, R(2) = 0.350, p < 0.001). Significant correlations were also observed between CBF and CBV (r = -0.153, R(2) = 0.023, p < 0.001), CBF and MTT (r = -0.580, R(2) = 0.337, p < 0.001) and MTT and CBV (r = 0.763, R(2) = 0.582, p < 0.001). Perfusion CT is useful to evaluate the hemodynamic state of patients with chronic major cerebral artery occlusive disorders.
本研究通过将灌注计算机断层扫描（CT）的结果与碘-123 碘安非他明（[(123)I]IMP）单光子发射计算机断层扫描（SPECT）的结果进行比较，探讨了灌注 CT 在评估慢性颈内动脉（ICA）闭塞患者中的实用性。25 例慢性 ICA 闭塞患者在同一天接受了灌注 CT 检查，以测量脑血流量（CBF）、脑血容量（CBV）和平均通过时间（MTT），并接受了[(123)I]IMP SPECT 检查以测量局部 CBF。观察到 SPECT 测量的局部 CBF 与灌注 CT 测量的 CBF 之间存在显著相关性（r = 0.659，R(2) = 0.434，p < 0.001），局部 CBF 与 CBV 之间（r = -0.406，R(2) = 0.165，p < 0.001）以及局部 CBF 与 MTT 之间（r = -0.592，R(2) = 0.350，p < 0.001）也存在显著相关性。CBF 与 CBV 之间（r = -0.153，R(2) = 0.023，p < 0.001）、CBF 与 MTT 之间（r = -0.580，R(2) = 0.337，p < 0.001）以及 MTT 与 CBV 之间（r = 0.763，R(2) = 0.582，p < 0.001）也观察到显著相关性。灌注 CT 有助于评估慢性大脑主要动脉闭塞性疾病患者的血流动力学状态。
