基于体素的320排区域探测器CT全脑CT灌注与碘123碘安非他明脑灌注SPECT在脑血管疾病患者中的相关性研究
Voxel-based correlation between whole-brain CT perfusion with 320-row area detector ct and iodine 123 iodoamphetamine brain perfusion spect in patients with cerebrovascular disease.
作者信息
Murayama Kazuhiro, Toyama Hiroshi, Hayakawa Motoharu, Imizu Shuei, Soma Tsutomu, Taniguchi Akira, Katada Kazuhiro
机构信息
From the *Department of Radiology and †Neurosurgery, Fujita Health University, Toyoake, Japan; ‡Division of Nuclear Medicine, Graduate School of Medicine, University of Tokyo, Japan; Software Development Group, Product Management and Marketing Department., Sales and Marketing Division, FUJIFILM RI Pharma Co., Ltd., Japan; §Clinical Application Research Center, Toshiba Medical Systems Corporation, Otawara, Japan; and ∥Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University, Toyoake, Japan.
出版信息
J Comput Assist Tomogr. 2014 Sep-Oct;38(5):639-46. doi: 10.1097/RCT.0000000000000110.
OBJECTIVE
We compared cerebral blood flow (CBF) measured using computed tomographic (CT) perfusion (CTP) and N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion single-photon emission computed tomography (SPECT).
METHODS
We used a 320-row area detector CT and N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion SPECT under similar conditions in patients with chronic cerebrovascular disease. Images were automatically aligned 3-dimensionally for voxel-by-voxel comparisons.
RESULTS
Linear positive correlations were observed between CTP-CBF including high-blood-flow areas and SPECT-CBF over the whole brain (r = 0.001-0.6, P < 0.01), superior cerebral level (r = 0.45-0.93, P < 0.01), basal ganglia level (r = 0.44-0.77, P < 0.01), and skull base (r = 0.02-0.66, P < 0.01). Correlations between CTP-CBF excluding high-blood-flow areas were significantly higher (P < 0.0001).
CONCLUSIONS
Computed tomographic perfusion overestimated CBF compared with SPECT and showed poor correlation at the skull base. Computed tomographic perfusion CTP excluding high-blood-flow areas improved the correlation over the whole brain in patients with chronic cerebrovascular disease.
目的
我们比较了使用计算机断层扫描（CT）灌注（CTP）和N-异丙基-p-[(123)I]-碘安非他明脑灌注单光子发射计算机断层扫描（SPECT）测量的脑血流量（CBF）。
方法
我们在慢性脑血管疾病患者中，于相似条件下使用320排区域探测器CT和N-异丙基-p-[(123)I]-碘安非他明脑灌注SPECT。图像进行了自动三维对齐，以便逐体素比较。
结果
在全脑范围内，包括高血流区域的CTP-CBF与SPECT-CBF之间观察到线性正相关（r = 0.001 - 0.6，P < 0.01），在大脑上水平（r = 0.45 - 0.93，P < 0.01）、基底节水平（r = 0.44 - 0.77，P < 0.01）和颅底（r = 0.02 - 0.66，P < 0.01）。排除高血流区域的CTP-CBF之间的相关性显著更高（P < 0.0001）。
结论
与SPECT相比，CT灌注高估了CBF，并且在颅底显示出较差的相关性。在慢性脑血管疾病患者中，排除高血流区域的CT灌注CTP改善了全脑的相关性。
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