兔膝关节内侧间室的体内负荷
In vivo loads in the medial compartment of the rabbit knee.
作者信息
Coughlin Kathryn M, Peura Glenn D, Fleming Braden C, Hallock Scott, Beynnon Bruce D
机构信息
Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, University of Vermont, Burlington, VT 05405, USA.
出版信息
Clin Biomech (Bristol). 2005 Nov;20(9):1007-9. doi: 10.1016/j.clinbiomech.2005.06.015.
BACKGROUND
The compressive loads produced in the medial compartment of a rabbit knee during hopping are unknown, and necessary for the development of an animal model to study unicompartmental osteoarthritis.
METHODS
In an effort to obtain such data, a surgical procedure was developed to insert a pressure sensor into the medial tibial compartment of a New Zealand white rabbit knee joint, and an inactive sensor of the same thickness into the lateral tibial compartment. After the rabbits recovered from anesthesia, contact pressure was measured as the rabbits hopped.
FINDINGS
The average peak pressure in the medial compartment was 60 N/cm2 (SD 16), a value that corresponds to 39% of the animals' body weight (range: 21-61%, SD 11%).
INTERPRETATION
This is the first report of measured in vivo pressures associated with the load transmitted through the medial compartment of the skeletally mature New Zealand White rabbit, a model frequently used to study the progression of osteoarthritis.
背景
兔子膝关节内侧间室在跳跃过程中产生的压缩负荷尚不清楚，而这对于研究单髁骨关节炎的动物模型的建立是必要的。
方法
为了获取此类数据，开发了一种外科手术，将压力传感器插入新西兰白兔膝关节的内侧胫骨间室，并将相同厚度的非活性传感器插入外侧胫骨间室。兔子从麻醉中恢复后，在其跳跃时测量接触压力。
结果
内侧间室的平均峰值压力为60 N/cm²（标准差16），该值相当于动物体重的39%（范围：21 - 61%，标准差11%）。
解读
这是关于通过骨骼成熟的新西兰白兔内侧间室传递的负荷所产生的体内压力测量的首份报告，该模型常用于研究骨关节炎的进展。
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