Suppr超能文献

胚胎植入中的脂质信号传导。

Lipid signaling in embryo implantation.

作者信息

Wang Haibin, Dey Sudhansu K

机构信息

Department of Pediatrics, Division of Reproductive & Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

出版信息

Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):84-102. doi: 10.1016/j.prostaglandins.2004.09.013.

Abstract

A reciprocal interaction between the implantation-competent blastocyst and the receptive uterus is required for successful implantation. Although various molecular pathways are known to participate in this cross-talk, a comprehensive understanding of the implantation process is still missing. Gene expression studies and genetically engineered mouse models have provided evidence that lipid mediators serve as important signaling molecules in coordinating the series of events during early pregnancy including preimplantation embryo formation and development, implantation and postimplantation growth. This review focuses on the roles of two groups of lipid mediators, prostaglandins (PGs) and endocannabinoids, during early pregnancy. Our laboratory has shown that while PGs generated by the cPLA2-cyclooxygenase (COX) system are essential to ovulation, fertilization, and implantation, endocannabinoids are important for synchronizing preimplantation embryo development with uterine receptivity for implantation. A better understanding of these molecular signaling pathways is hoped to generate new strategies to correct implantation failure and improve pregnancy rates in women.

摘要

成功着床需要具备着床能力的囊胚与处于接受态的子宫之间进行相互作用。尽管已知多种分子途径参与了这种相互交流,但仍缺乏对着床过程的全面理解。基因表达研究和基因工程小鼠模型已提供证据表明,脂质介质在协调早期妊娠期间的一系列事件(包括着床前胚胎的形成与发育、着床及着床后生长)中作为重要的信号分子发挥作用。本综述聚焦于两类脂质介质,即前列腺素(PGs)和内源性大麻素在妊娠早期的作用。我们实验室已表明,虽然由胞质型磷脂酶A2-环氧化酶(COX)系统产生的PGs对排卵、受精和着床至关重要,但内源性大麻素对于使着床前胚胎发育与子宫接受着床的能力同步化很重要。希望对这些分子信号通路有更深入的了解能够产生新的策略,以纠正着床失败并提高女性的妊娠率。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验