Sällström Björn, Andersson Siv G E
Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden.
Curr Opin Microbiol. 2005 Oct;8(5):579-85. doi: 10.1016/j.mib.2005.08.002.
More than 20 alpha-proteobacterial genomes are currently available. These range in size from 1-9 Mb and represent excellent model systems for evolutionary studies of the organizational features of bacterial genomes. Computational inferences have shown that genome reductions have occurred independently in lineages such as Rickettsia and Bartonella that are associated with intracellular lifestyles. Analyses of these reduced genomes have provided insights into the evolution of vector-borne transmission pathways. Further research into the population biology of bacteria, arthropods and vertebrate hosts will help to refine the biology of host-pathogen interactions and will facilitate the design of vaccines and vector-control programs.
目前已有20多个α-变形菌纲细菌的基因组。这些基因组大小从1 - 9兆碱基对不等，是研究细菌基因组组织特征进化的优秀模型系统。计算推断表明，在诸如立克次氏体和巴尔通体等与细胞内生存方式相关的谱系中，基因组缩减是独立发生的。对这些缩减基因组的分析为媒介传播途径的进化提供了见解。对细菌、节肢动物和脊椎动物宿主群体生物学的进一步研究将有助于完善宿主 - 病原体相互作用的生物学，并促进疫苗和媒介控制计划的设计。
