Van Vliet Monique, Spruit Martijn A, Verleden Geert, Kasran Ahmad, Van Herck Erik, Pitta Fabio, Bouillon Roger, Decramer Marc
Respiratory Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium.
Am J Respir Crit Care Med. 2005 Nov 1;172(9):1105-11. doi: 10.1164/rccm.200501-114OC. Epub 2005 Aug 11.
Circulating levels of testosterone and gonadotrophins of patients with chronic obstructive pulmonary disease (COPD) have never been compared with those of elderly men with normal pulmonary function. Moreover, the relationship of hypogonadism with quadriceps muscle weakness and exercise intolerance has been studied scarcely in men with COPD.
To compare circulating levels of hormones of the pituitary-gonadotrophic axis of men with COPD with those of age-matched control subjects. Moreover, to study the relationship of hypogonadism with quadriceps muscle force, 6-min walking distance, and systemic markers of inflammation in the patients.
Circulating levels of follicle-stimulating hormone, luteinizing hormone, testosterone, and sex hormone-binding globulin were determined, and free testosterone was calculated in 78 patients (FEV1: 44 +/- 17% of the predicted values) and 21 control subjects. Moreover, quadriceps muscle force, 6-min walking distance, number of pack-yr, and systemic inflammation were determined.
Follicle-stimulating hormone and luteinizing hormone were higher in the patients, whereas testosterone was lower (p < or = 0.05). The latter finding was also present in 48 non-steroid-using patients with normal blood gases. Low androgen status was significantly related to quadriceps muscle weakness (r = 0.48) and C-reactive protein (r = -0.39) in the patients, but not to exercise intolerance, the number of pack-yr, or increased circulating levels of interleukin 8 or soluble receptors of tumor necrosis factor alpha.
In contrast to exercise intolerance, quadriceps muscle weakness is related to low circulating levels of testosterone in men with COPD.
慢性阻塞性肺疾病（COPD）患者的睾酮和促性腺激素循环水平从未与肺功能正常的老年男性进行过比较。此外，在患有COPD的男性中，性腺功能减退与股四头肌无力和运动不耐受之间的关系鲜有研究。
比较患有COPD的男性与年龄匹配的对照受试者垂体 - 性腺轴激素的循环水平。此外，研究患者中性腺功能减退与股四头肌力量、6分钟步行距离和炎症全身标志物之间的关系。
测定了78例患者（FEV1：预测值的44±17%）和21例对照受试者的促卵泡激素、促黄体生成素、睾酮和性激素结合球蛋白的循环水平，并计算了游离睾酮。此外，还测定了股四头肌力量、6分钟步行距离、吸烟包年数和全身炎症情况。
患者的促卵泡激素和促黄体生成素较高，而睾酮较低（p≤0.05）。在48例血气正常的非使用类固醇患者中也有后一项发现。低雄激素状态与患者的股四头肌无力（r = 0.48）和C反应蛋白（r = -0.39）显著相关，但与运动不耐受、吸烟包年数或白细胞介素8或肿瘤坏死因子α可溶性受体循环水平升高无关。
与运动不耐受不同，股四头肌无力与患有COPD的男性睾酮循环水平低有关。
