Kemény Vendel, Molnár Sándor, Andrejkovics Mónika, Makai Attila, Csiba László
Department of Neurology, PM Flór Ferenc County Hospital, H-2143 Kistarcsa, and Department of Neurology, University of Debrecen, Hungary.
J Clin Pharmacol. 2005 Sep;45(9):1048-54. doi: 10.1177/0091270005279363.
A double-blind, prospective, randomized, placebo-controlled clinical trial was carried out to test the acute and long-term hemodynamical and beneficial cognitive effects of the vasoactive agent vinpocetine on patients suffering from multiple cerebral infarcts by means of functional transcranial Doppler examinations and by neuropsychological tests. Twenty-six patients (17 men, 9 women) with multiple cerebral infarctions, aged between 50 and 83 years (mean age+/-SD=63.4+/-9.39 years) were examined, 14 of whom received vinpocetine and 12 placebo. The functional transcranial Doppler included breath-holding tests, finger movement, word fluency, and picture-discrimination tasks. Twenty-five patients were assessed by neuropsychological battery. No serious side effect was found in the vinpocetine group. The flow velocities were significantly lower in the acute phase after breath holding in the vinpocetine group than in the placebo group. Three months later, the vinpocetine patients did not show any significant worsening in digit span backward test, while the placebo group did. No other significant differences in the neuropsychological test could be detected between the treatment and the placebo groups. Longer lasting and higher dosage of vinpocetine therapy is suggested to prove its potential effect.
进行了一项双盲、前瞻性、随机、安慰剂对照临床试验，旨在通过功能性经颅多普勒检查和神经心理学测试，检验血管活性药物长春西汀对多发性脑梗死患者的急性和长期血液动力学及有益认知影响。研究对26例多发性脑梗死患者（17例男性，9例女性）进行了检查，年龄在50至83岁之间（平均年龄±标准差=63.4±9.39岁），其中14例接受长春西汀治疗，12例接受安慰剂治疗。功能性经颅多普勒检查包括屏气试验、手指运动、语言流畅性和图片辨别任务。25例患者接受了神经心理成套测验评估。长春西汀组未发现严重副作用。长春西汀组屏气后急性期的血流速度显著低于安慰剂组。三个月后，长春西汀治疗的患者在倒背数字测试中未出现任何显著恶化，而安慰剂组出现了恶化。治疗组和安慰剂组在神经心理学测试中未发现其他显著差异。建议采用持续时间更长、剂量更高的长春西汀疗法来证明其潜在效果。
