da Graça Krupa Fabiana, Cecatti José Guilherme, de Castro Surita Fernanda Garanhani, Milanez Helaine Maria Besteti Pires, Parpinelli Mary Angela
Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Universidade Estadual de Campinas-UNICAMP, Campinas, São Paulo, Brazil.
BJOG. 2005 Sep;112(9):1284-90. doi: 10.1111/j.1471-0528.2005.00700.x.
To compare the effectiveness of immediate induction of labour with vaginal misoprostol versus expectant management for 24 hours followed by oxytocin induction in women with premature rupture of membranes at term (term PROM).
An open, randomised, controlled trial.
Public university hospital in Campinas City, Brazil.
One hundred and fifty pregnancies, half of them allocated to each group.
Statistical analysis used Student's t test, the chi2 test, Fisher's exact test, survival analysis and risk ratio estimates with 95% CI.
Latency period, recruitment to delivery period, period of hospitalisation, mode of delivery, contractility pattern, fetal wellbeing, labour and delivery complications, neonatal and maternal morbidity.
Both groups had similar general characteristics, but the misoprostol group had a significantly shorter latency period (9.4 vs 15.8 hours), a shorter time interval from recruitment to delivery (18.9 vs 27.5 hours), a shorter period of maternal hospitalisation and a slightly higher proportion of alterations of contractility when compared with the expectant group. Caesarean section rates were 20% in the misoprostol group and 30.7% in the other. There were no differences between them regarding fetal wellbeing, complications during labour and delivery and neonatal or postpartum maternal morbidity. Within 24 hours, 44% of women had delivered in the expectant group against 73.3% in the misoprostol group.
Immediate labour induction with misoprostol in cases of term PROM shortens the latency period, the total time between recruitment to delivery and the time of maternal hospitalisation, increasing the occurrence of alterations of contractility without any maternal and perinatal outcomes disadvantages.
比较足月胎膜早破（足月PROM）女性中，阴道使用米索前列醇即刻引产与期待治疗24小时后使用缩宫素引产的效果。
开放、随机、对照试验。
巴西坎皮纳斯市的公立大学医院。
150例妊娠，每组分配一半。
采用学生t检验、卡方检验、Fisher精确检验、生存分析以及95%置信区间的风险比估计进行统计分析。
潜伏期、从入院到分娩的时间、住院时间、分娩方式、宫缩模式、胎儿状况、分娩并发症、新生儿及产妇发病率。
两组一般特征相似，但与期待治疗组相比，米索前列醇组潜伏期显著缩短（9.4小时对15.8小时），从入院到分娩的时间间隔更短（18.9小时对27.5小时），产妇住院时间更短，宫缩改变比例略高。米索前列醇组剖宫产率为20%，另一组为30.7%。两组在胎儿状况、分娩期间并发症以及新生儿或产后产妇发病率方面无差异。24小时内，期待治疗组44%的女性分娩了，而米索前列醇组为73.3%。
足月PROM病例中，米索前列醇即刻引产可缩短潜伏期、从入院到分娩的总时间以及产妇住院时间，并增加宫缩改变的发生率，且无任何母婴结局方面的劣势。
