Visconti A, Minervini F, Solfrizzo M, Bottalico C, Lucivero G
Istituto Tossine e Micotossine da Parassiti Vegetali, C.N.R., Bari, Italy.
Appl Environ Microbiol. 1992 Feb;58(2):769-72. doi: 10.1128/aem.58.2.769-772.1992.
The relationship between the toxicities of crude extracts and purified toxins of Fusarium spp. belonging to the section Sporotrichiella has been assessed. Toxicity was determined on the basis of death of Artemia salina larvae and of viability and blastogenic response of bovine and human lymphocytes. Trichothecene-producing strains of Fusarium sporotrichioides and Fusarium poae were toxic to A. salina and to lymphocyte blastogenesis. A strain of Fusarium tricinctum, producing visoltricin and chlamydosporol, induced differentiated activity in different bioassays (toxicity to A. salina but only minor activity against lymphocyte blastogenesis). Other, non-toxin-producing strains of Fusarium chlamydosporum, F. poae, and F. tricinctum were not active in the tested biosystems.
对属于孢枝孢菌属的镰刀菌粗提物和纯化毒素的毒性之间的关系进行了评估。毒性是根据卤虫幼虫的死亡以及牛和人淋巴细胞的活力和增殖反应来确定的。产生单端孢霉烯的禾谷镰刀菌和梨孢镰刀菌菌株对卤虫和淋巴细胞增殖有毒性。一株产生维索曲菌素和厚垣孢子醇的三线镰刀菌菌株在不同的生物测定中诱导了分化活性（对卤虫有毒性，但对淋巴细胞增殖只有轻微活性）。其他不产生毒素的厚垣孢子镰刀菌、禾谷镰刀菌和三线镰刀菌菌株在测试的生物系统中没有活性。
