Pekkanen L, Rusi M
Pharmacol Biochem Behav. 1979 Nov;11(5):575-9. doi: 10.1016/0091-3057(79)90044-3.
The effects of dietary deficiency and excess of niacin and riboflavin on voluntary drinking of 10% (v/v) ethanol were studied in male rats. The effectiveness of dietary deficiency and excess of both niacin and riboflavin on tissue levels of these vitamins was demonstrated by measurements of urinary N1-methylnicotinamide and blood glutathione reductase (EC 1.6.4.2) activity. A high-niacin diet containing 75 mg niacin/kg food decreased ethanol intake by about 36% compared to the control diet containing 15 mgniacin/kg. Niacin or riboflavin deficiency and a high-riboflavin diet containing 40 mg rtary levels of niacin or riboflavin did not influence on ethanol elimination rate or levels of blood acetaldehyde during ethanol oxidation. Therefore, blood acetaldehyde was not responsible for the decreased ethanol intake of rats fed with a high-niacin diet. It was concluded that the increased ethanol intake caused by dietary deprivation of B-vitamin complex found in earlier studies is not a result of deficiency of niacin or riboflavin but niacin may be involved in the decrease in ethanol drinking, which follows dietary B-vitamin complex supplementation.
在雄性大鼠中研究了饮食中烟酸和核黄素缺乏及过量对其自愿饮用10%（v/v）乙醇的影响。通过测量尿中N1-甲基烟酰胺和血液谷胱甘肽还原酶（EC 1.6.4.2）活性，证明了饮食中烟酸和核黄素缺乏及过量对这些维生素组织水平的影响。与含15 mg烟酸/kg的对照饮食相比，含75 mg烟酸/kg食物的高烟酸饮食使乙醇摄入量降低了约36%。烟酸或核黄素缺乏以及含40 mg核黄素/kg的高核黄素饮食对乙醇氧化过程中的乙醇消除率或血液乙醛水平没有影响。因此，血液乙醛不是导致高烟酸饮食喂养的大鼠乙醇摄入量降低的原因。得出的结论是，早期研究中发现的饮食中B族维生素复合物缺乏导致的乙醇摄入量增加不是烟酸或核黄素缺乏的结果，但烟酸可能参与了饮食中补充B族维生素复合物后乙醇饮用量的减少。
