Kodentsova V M, Sadykova R E, Dreval' A V, Vrzhesinskaia O A, Sokol'nikov A A, Beketova N A
Probl Endokrinol (Mosk). 1992 Nov-Dec;38(6):53-4.
Water-soluble group B vitamins metabolism was studied over the course of streptozotocin-induced diabetes mellitus in rats fed semisynthetic isocaloric diets containing 18 and 50% of protein. A high-protein diet in diabetes mellitus does not influence riboflavin metabolism disordered in this disease but reduced 4-pyridoxyl acid excretion to the level characteristic of healthy animals. The observed trend to an increase of liver nicotinamide coenzymes levels and of 1-methylnicotinamide urinary excretion reflects increased niacin synthesis from the diet protein tryptophan, for niacin level is reduced in diabetes.
在喂食含18%和50%蛋白质的半合成等热量饮食的大鼠中，研究了链脲佐菌素诱导的糖尿病病程中水溶性B族维生素的代谢情况。糖尿病中的高蛋白饮食并不影响该病中紊乱的核黄素代谢，但可将4-吡啶氧酸排泄量降低至健康动物的特征水平。观察到的肝脏烟酰胺辅酶水平升高和尿中1-甲基烟酰胺排泄增加的趋势反映了从饮食蛋白质色氨酸合成烟酸的增加，因为糖尿病中烟酸水平降低。
