Dimitriou Rozalia, Tsiridis Eleftherios, Giannoudis Peter V
Academic Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, St James's University Hospital, Backett Street, LS9 7TF, UK.
Injury. 2005 Dec;36(12):1392-404. doi: 10.1016/j.injury.2005.07.019. Epub 2005 Aug 15.
Fracture healing is a complex physiological process. It involves the coordinated participation of haematopoietic and immune cells within the bone marrow in conjunction with vascular and skeletal cell precursors, including mesenchymal stem cells (MSCs) that are recruited from the surrounding tissues and the circulation. Multiple factors regulate this cascade of molecular events by affecting different sites in the osteoblast and chondroblast lineage through various processes such as migration, proliferation, chemotaxis, differentiation, inhibition, and extracellular protein synthesis. An understanding of the fracture healing cellular and molecular pathways is not only critical for the future advancement of fracture treatment, but it may also be informative to our further understanding of the mechanisms of skeletal growth and repair as well as the mechanisms of aging.
骨折愈合是一个复杂的生理过程。它涉及骨髓内造血细胞和免疫细胞与血管及骨骼细胞前体的协同参与，这些细胞前体包括从周围组织和循环系统募集而来的间充质干细胞（MSC）。多种因素通过迁移、增殖、趋化性、分化、抑制和细胞外蛋白质合成等各种过程影响成骨细胞和软骨细胞谱系中的不同位点，从而调节这一系列分子事件。了解骨折愈合的细胞和分子途径不仅对骨折治疗的未来进展至关重要，而且可能有助于我们进一步理解骨骼生长和修复机制以及衰老机制。
