Gruber Reinhard, Koch Hannjörg, Doll Bruce A, Tegtmeier Florian, Einhorn Thomas A, Hollinger Jeffrey O
Department of Oral Surgery, Medical University of Vienna, Austria.
Exp Gerontol. 2006 Nov;41(11):1080-93. doi: 10.1016/j.exger.2006.09.008. Epub 2006 Nov 7.
Clinical experience gives rise to the impression that there are differences in fracture healing in different age groups. It is evident that fractures heal more efficiently in children than in adults. However, minimal objective knowledge exists to evaluate this assumption. Temporal, spatial, and cellular quantitative and qualitative interrelationships, as well as signaling molecules and extracellular matrix have not been comprehensively and adequately elucidated for fracture healing in the geriatric skeleton. The biological basis of fracture healing will provide a context for revealing the pathophysiology of delayed or even impaired bone regeneration in the elderly. We will summarize experimental studies on age-related changes at the cellular and molecular level that will add to the pathophysiological understanding of the compromised bone regeneration capacity believed to exist in the elderly patient. We will suggest why this understanding would be useful for therapeutics focused on bone regeneration, in particular fracture healing at an advanced age.
临床经验使人产生这样的印象，即不同年龄组的骨折愈合存在差异。显然，儿童骨折的愈合比成人更有效。然而，用于评估这一假设的客观知识却很少。对于老年骨骼骨折愈合的时间、空间和细胞的定量与定性相互关系，以及信号分子和细胞外基质，尚未得到全面和充分的阐明。骨折愈合的生物学基础将为揭示老年人延迟甚至受损的骨再生病理生理学提供背景。我们将总结在细胞和分子水平上与年龄相关变化的实验研究，这些研究将增进我们对老年患者骨再生能力受损的病理生理学理解。我们将提出为什么这种理解对于专注于骨再生，特别是高龄骨折愈合的治疗方法会有用。
