20-羟基二十碳四烯酸在人尿液中以葡萄糖醛酸共轭物的形式排泄。
20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine.
作者信息
Prakash C, Zhang J Y, Falck J R, Chauhan K, Blair I A
机构信息
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232.
出版信息
Biochem Biophys Res Commun. 1992 Jun 15;185(2):728-33. doi: 10.1016/0006-291x(92)91686-k.
20-hydroxyeicosatetraenoic acid, a major renal P-450 metabolite of arachidonic acid, has been quantified in human urine using capillary gas chromatography/electron capture negative ion chemical ionization mass spectrometry. The urinary excretion of 20-hydroxyeicosatetraenoic acid was in the low pg/ml range. However, treatment of urine with beta-glucuronidase resulted in a 13- to 28-fold increase in its concentration. This suggests 20-hydroxyeicosatetraenoic acid differs from other eicosanoids in that it is excreted primarily as a glucuronide conjugate.
20-羟基二十碳四烯酸是花生四烯酸主要的肾脏P-450代谢产物，已通过毛细管气相色谱/电子捕获负离子化学电离质谱法对其在人尿液中的含量进行了定量分析。20-羟基二十碳四烯酸的尿排泄量处于低皮克/毫升范围内。然而，用β-葡萄糖醛酸酶处理尿液后，其浓度增加了13至28倍。这表明20-羟基二十碳四烯酸与其他类花生酸不同，它主要以葡萄糖醛酸共轭物的形式排泄。
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