Freemont A J, Hoyland J, Fielding P, Hodson N, Jayson M I
Department of Rheumatology, University of Manchester Medical School, U.K.
Br J Dermatol. 1992 Jun;126(6):561-8. doi: 10.1111/j.1365-2133.1992.tb00100.x.
Various parameters for assessing endothelial cell (EC) metabolism, including immunohistochemistry and adenosine uptake, have been compared in the clinically uninvolved skin of patients with diffuse systemic sclerosis (DSS), CREST, incomplete CREST syndrome (ICREST), primary Raynaud's disease (1 degree RD) and normal controls. Evidence of platelet adhesion to EC, decreased EC storage of factor VII-related antigen, changes in EC morphology and decreased adenosine uptake by EC, were found in the dermal microvasculature of normal skin of patients with DSS, CREST and ICREST, but not in 1 degree RD. These data indicate that a generalized microvascular endothelial dysfunction is present in the skin of patients with the systemic forms of scleroderma.
在弥漫性系统性硬化症（DSS）、CREST综合征、不完全CREST综合征（ICREST）、原发性雷诺病（1度RD）患者以及正常对照者的临床未受累皮肤中，对评估内皮细胞（EC）代谢的各种参数进行了比较，这些参数包括免疫组织化学和腺苷摄取。在DSS、CREST和ICREST患者的正常皮肤真皮微血管中，发现了血小板黏附于EC的证据、EC中因子VII相关抗原储存减少、EC形态改变以及EC对腺苷摄取减少，但在1度RD患者中未发现这些情况。这些数据表明，系统性硬皮病患者的皮肤存在广泛性微血管内皮功能障碍。
