Goralczyk R, Luz A, Erfle V, Schmidt J
GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Institut für Molekulare Virologie, Neuherberg, Deutschland.
Zentralbl Pathol. 1992 Apr;138(2):97-102.
A tumour cell line was established from a non-metastatic osteosarcoma which had developed in the right femur after infection of a newborn mouse with FBR osteosarcoma virus (FBR MSV). After 20 cell culture passages and injection of the cells into newborn syngeneic mice, the animals developed fibrosarcomas on the site of injection. Metastatic lung tumours were detected in 50% of the mice. Metastatic tumour growth was preferentially observed in the walls of large blood vessels and in subpleural zones. Large areas of the metastatic tumours resembled mature connective tissue. This model of in vitro progression from a primary non-metastasizing osteosarcoma to a neoplasm with particular metastatic potency, though with a growth pattern similar to fibromatosis may serve as a useful system to study the different steps of metastatic progression, distinct tropism of invasive cells and fibrous maturation of metastatic tumours.
一株肿瘤细胞系源自一只新生小鼠感染FBR骨肉瘤病毒（FBR MSV）后在右股骨发生的非转移性骨肉瘤。经过20次细胞培养传代并将细胞注射到同基因新生小鼠体内后，这些动物在注射部位发生了纤维肉瘤。在50%的小鼠中检测到转移性肺肿瘤。转移性肿瘤生长优先出现在大血管壁和胸膜下区域。转移性肿瘤的大片区域类似于成熟结缔组织。这种从原发性非转移性骨肉瘤体外进展为具有特定转移潜能的肿瘤，尽管其生长模式类似于纤维瘤病的模型，可作为研究转移进展的不同步骤、侵袭细胞的不同嗜性以及转移性肿瘤纤维成熟的有用系统。
