Meyvisch C, Mareel M
Invasion Metastasis. 1985;5(4):185-92.
MO4 mouse fibrosarcoma cells metastasized to the lungs and to the regional lymph nodes from a subcutaneous tumour in the pinna when they were derived from a tumour in the tail or from lung metastases. In contrast, no metastases were found when MO4 cells were derived from a tumour in the pinna or from the parent cell line. Cells from tumours in the pinna produced metastatic tumours when they were implanted in the tail but not in the pinna. The type of implant-spheroidal cell aggregate, freshly cut tumour fragment or precultured tumour fragment- had no influence on the metastatic behaviour of the resulting tumour. These observations confirm the concept that local factors at the growth site of a tumour influence the metastatic behaviour of that tumour.
当MO4小鼠纤维肉瘤细胞源自尾部肿瘤或肺转移瘤时，皮下耳廓肿瘤会转移至肺部和局部淋巴结。相比之下，当MO4细胞源自耳廓肿瘤或亲代细胞系时，未发现转移现象。耳廓肿瘤的细胞植入尾部时会产生转移性肿瘤，但植入耳廓时则不会。植入物的类型——球形细胞聚集体、新鲜切割的肿瘤碎片或预培养的肿瘤碎片——对所产生肿瘤的转移行为没有影响。这些观察结果证实了这样一个概念，即肿瘤生长部位的局部因素会影响该肿瘤的转移行为。
