Vashisht Arvind, Wadsworth Fred, Carey Adam, Carey Beverley, Studd John
Chelsea and Westminster Hospital, London, UK.
Gynecol Endocrinol. 2005 Aug;21(2):101-5. doi: 10.1080/09513590500128583.
Natural progesterone creams are gaining popularity as a possible treatment for menopausal symptoms, and many women may be using them with estrogen. We planned to evaluate, using an open plan study, the systemic absorption of a combination of transdermal estrogen and progesterone. Women applied transdermal progesterone 40 mg and transdermal estrogen 1 mg daily over 48 weeks. Women were assessed at intervals of 12 weeks. Significant increases in plasma levels of progesterone and estradiol were seen after 12 weeks, although only low plasma progesterone levels were found (median 2.5 nmol/l) and no further increase was noted over the remainder of the study period. A significant correlation was found between plasma levels of the two hormone (r = 0.315, p = 0.045). Women reported significant reductions in menopausal symptoms, as measured by the Green Climacteric Scale, after 24 and 48 weeks of combined treatment. There may be similar mechanisms of absorption of the two hormones, although the doses used in our study produced sub-luteal levels of progesterone. There was no evidence of accumulation of progesterone with time, and further study is needed to assess the efficacy and safety of this combination of hormones.
天然孕酮乳膏作为一种可能治疗更年期症状的方法正越来越受欢迎，许多女性可能将其与雌激素一起使用。我们计划采用开放研究来评估经皮雌激素和孕酮联合用药后的全身吸收情况。女性在48周内每天使用40毫克经皮孕酮和1毫克经皮雌激素。每隔12周对女性进行评估。12周后，孕酮和雌二醇的血浆水平显著升高，尽管仅发现较低的血浆孕酮水平（中位数为2.5纳摩尔/升），且在研究期的剩余时间内未观察到进一步升高。两种激素的血浆水平之间存在显著相关性（r = 0.315，p = 0.045）。联合治疗24周和48周后，通过格林更年期量表测量，女性报告更年期症状显著减轻。两种激素可能有相似的吸收机制，尽管我们研究中使用的剂量产生的孕酮水平低于黄体期水平。没有证据表明孕酮会随时间积累，需要进一步研究来评估这种激素组合的疗效和安全性。
