用于绝经激素治疗的生物同源激素：主题变奏
Bioidentical hormones for menopausal hormone therapy: variation on a theme.
作者信息
Fugh-Berman Adriane, Bythrow Jenna
机构信息
Department of Physiology and Biophysics, Georgetown University School of Medicine, 571460, Washington, DC 20052-1460, USA.
出版信息
J Gen Intern Med. 2007 Jul;22(7):1030-4. doi: 10.1007/s11606-007-0141-4. Epub 2007 Mar 7.
Abstract
BACKGROUND
Progesterone creams and natural or bioidentical compounded estrogen preparations are being promoted to consumers as safe alternatives to conventional menopausal hormone therapy and as health-promoting tonics. No reliable data support these claims.
SAFETY
Natural hormones, including estradiol, estriol, estrone, and progesterone, can be expected to have the same adverse event profile as conventional menopausal hormone regimens.
SALIVARY HORMONE TESTS
Salivary tests may be used to persuade asymptomatic consumers to use hormones (or symptomatic patients to use higher doses than those needed to mitigate symptoms), a practice that can be expected to result in adverse events.
摘要
背景
孕酮乳膏以及天然或生物等效的复合雌激素制剂作为传统绝经激素疗法的安全替代品以及促进健康的滋补品向消费者进行推广。但并无可靠数据支持这些说法。
安全性
天然激素，包括雌二醇、雌三醇、雌酮和孕酮，预计会与传统绝经激素疗法有相同的不良事件谱。
唾液激素检测
唾液检测可能被用于说服无症状的消费者使用激素（或有症状的患者使用高于缓解症状所需剂量的激素），这种做法预计会导致不良事件。
相似文献
1
Bioidentical hormones for menopausal hormone therapy: variation on a theme.用于绝经激素治疗的生物同源激素：主题变奏
J Gen Intern Med. 2007 Jul;22(7):1030-4. doi: 10.1007/s11606-007-0141-4. Epub 2007 Mar 7.
2
Compounded or confused? Bioidentical hormones and menopausal health.是复合制剂还是混淆概念？生物同源激素与更年期健康
Menopause Int. 2011 Mar;17(1):16-8. doi: 10.1258/mi.2011.011009.
3
Bioidentical hormone therapy: a review of the evidence.生物同源激素疗法：证据综述
J Womens Health (Larchmt). 2007 Jun;16(5):600-31. doi: 10.1089/jwh.2006.0311.
4
The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?生物同源激素之争：在激素替代疗法中，生物同源激素（雌二醇、雌三醇和孕酮）是否比常用的合成激素更安全或更有效？
Postgrad Med. 2009 Jan;121(1):73-85. doi: 10.3810/pgm.2009.01.1949.
5
Risks and effectiveness of compounded bioidentical hormone therapy: a case series.复方生物等效激素疗法的风险与疗效：病例系列
J Womens Health (Larchmt). 2014 Aug;23(8):642-8. doi: 10.1089/jwh.2014.4770.
6
Bioidentical hormones for menopausal therapy.
Womens Health (Lond). 2008 Mar;4(2):163-71. doi: 10.2217/17455057.4.2.163.
7
Bioidentical hormone therapy: a panacea that lacks supportive evidence.生物同源激素疗法：一种缺乏支持证据的万灵药。
Curr Opin Obstet Gynecol. 2008 Aug;20(4):400-7. doi: 10.1097/GCO.0b013e3283081ae9.
8
Compounded bioidentical menopausal hormone therapy.复方生物等同更年期激素治疗。
Fertil Steril. 2012 Aug;98(2):308-12. doi: 10.1016/j.fertnstert.2012.06.002.
9
Use of compounded bioidentical hormone therapy in menopausal women: an opinion statement of the Women's Health Practice and Research Network of the American College of Clinical Pharmacy.复方生物同源激素疗法在绝经后女性中的应用：美国临床药师学会女性健康实践与研究网络的意见声明
Pharmacotherapy. 2014;34(4):410-23. doi: 10.1002/phar.1394. Epub 2014 Jan 4.
10
Bioidentical hormone therapy in menopause: relevance in dermatology.更年期的生物同源激素疗法：在皮肤科的相关性
Dermatol Online J. 2019 Jan 15;25(1):13030/qt4c20m28z.
引用本文的文献
1
INDIVIDUALIZATION OF CUSTOM COMPOUNDED HORMONE THERAPY IN A PATIENT WITH CHEMOTHERAPY INDUCED PREMATURE OVARIAN INSUFFICIENCY AND IMPAIRED LIVER FUNCTION - CASE REPORT.化疗所致卵巢早衰及肝功能受损患者定制化复合激素疗法的个体化——病例报告
Acta Clin Croat. 2019 Mar;58(1):167-172. doi: 10.20471/acc.2019.58.01.21.
2
Why women choose compounded bioidentical hormone therapy: lessons from a qualitative study of menopausal decision-making.女性为何选择复方生物同源激素疗法：绝经决策定性研究的经验教训
BMC Womens Health. 2017 Oct 2;17(1):97. doi: 10.1186/s12905-017-0449-0.
3
Bioidentical hormones, menopausal women, and the lure of the "natural" in U.S. anti-aging medicine.生物同源激素、更年期女性与美国抗衰老医学中“天然”的诱惑。
Soc Sci Med. 2015 May;132:79-87. doi: 10.1016/j.socscimed.2015.02.027. Epub 2015 Feb 19.
4
Defining bioidentical hormones for menopause-related symptoms.定义用于治疗更年期相关症状的生物同源激素。
Pharm Pract (Granada). 2011 Jan;9(1):16-22. doi: 10.4321/s1886-36552011000100003. Epub 2011 Mar 15.
5
Bioidentical hormone therapy: Nova Scotia pharmacists' knowledge and beliefs.生物同源激素疗法：新斯科舍省药剂师的知识与信念。
Pharm Pract (Granada). 2012 Jul;10(3):159-67. doi: 10.4321/s1886-36552012000300006. Epub 2012 Sep 30.
本文引用的文献
1
Effects of conjugated equine estrogen on stroke in the Women's Health Initiative.结合马雌激素对女性健康倡议研究中中风的影响。
Circulation. 2006 May 23;113(20):2425-34. doi: 10.1161/CIRCULATIONAHA.105.594077. Epub 2006 May 15.
2
Bleeding profiles and effects on the endometrium for women using a novel combination of transdermal oestradiol and natural progesterone cream as part of a continuous combined hormone replacement regime.采用新型经皮雌二醇与天然孕酮乳膏联合用药作为连续联合激素替代疗法一部分的女性的出血情况及对子宫内膜的影响。
BJOG. 2005 Oct;112(10):1402-6. doi: 10.1111/j.1471-0528.2005.00689.x.
3
A study to look at hormonal absorption of progesterone cream used in conjunction with transdermal estrogen.一项关于经皮雌激素联合使用的黄体酮乳膏激素吸收情况的研究。
Gynecol Endocrinol. 2005 Aug;21(2):101-5. doi: 10.1080/09513590500128583.
4
Over-the-counter progesterone cream produces significant drug exposure compared to a food and drug administration-approved oral progesterone product.与美国食品药品监督管理局批准的口服孕酮产品相比，非处方孕酮乳膏会产生显著的药物暴露。
J Clin Pharmacol. 2005 Jun;45(6):614-9. doi: 10.1177/0091270005276621.
5
Percutaneous administration of progesterone: blood levels and endometrial protection.
Menopause. 2005 Mar;12(2):232-7. doi: 10.1097/00042192-200512020-00019.
6
Effects of estrogen with and without progestin on urinary incontinence.雌激素联合或不联合孕激素对尿失禁的影响。
JAMA. 2005 Feb 23;293(8):935-48. doi: 10.1001/jama.293.8.935.
7
Investigation of product quality between extemporaneously compounded progesterone vaginal suppositories and an approved progesterone vaginal gel.自制黄体酮阴道栓与已获批的黄体酮阴道凝胶之间的产品质量研究。
Drug Dev Ind Pharm. 2004;30(10):1069-78. doi: 10.1081/ddc-200040251.
8
Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort.E3N-EPIC队列中不同类型激素替代疗法与乳腺癌风险的关系。
Int J Cancer. 2005 Apr 10;114(3):448-54. doi: 10.1002/ijc.20710.
9
Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study.结合马雌激素与绝经后女性可能患痴呆症和轻度认知障碍的发生率：女性健康倡议记忆研究
JAMA. 2004 Jun 23;291(24):2947-58. doi: 10.1001/jama.291.24.2947.
10
Bioidentical hormone therapy: a review.生物同源激素疗法综述
Menopause. 2004 May-Jun;11(3):356-67. doi: 10.1097/01.gme.0000094356.92081.ef.
Zotero 插件