Epigenetic silencing in embryogenesis.
作者信息
Meehan Richard R, Dunican Donncha S, Ruzov Alexey, Pennings Sari
机构信息
Human Genome Unit, Medical Research Council, Western General Hospital, Crewe Road, Edinburgh EH4 9XU, UK.
出版信息
Exp Cell Res. 2005 Oct 1;309(2):241-9. doi: 10.1016/j.yexcr.2005.06.023.
PMID:16112110
Abstract
Transcription profiling of early embryos emphasizes that differential gene expression is a fundamental control mechanism of development. Precise regulatory mechanisms operate on a background of epigenetic changes in chromatin composition, modification, and architecture that are integral for the development of a pluripotent embryo into an adult.
摘要
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