Meehan Richard R, Dunican Donncha S, Ruzov Alexey, Pennings Sari
Human Genome Unit, Medical Research Council, Western General Hospital, Crewe Road, Edinburgh EH4 9XU, UK.
Exp Cell Res. 2005 Oct 1;309(2):241-9. doi: 10.1016/j.yexcr.2005.06.023.
Transcription profiling of early embryos emphasizes that differential gene expression is a fundamental control mechanism of development. Precise regulatory mechanisms operate on a background of epigenetic changes in chromatin composition, modification, and architecture that are integral for the development of a pluripotent embryo into an adult.
