Hynes Catherine A, Baird Abigail A, Grafton Scott T
Department of Psychological and Brain Sciences, Dartmouth College, 6162 Moore Hall, Hanover, NH 03755, USA.
Neuropsychologia. 2006;44(3):374-83. doi: 10.1016/j.neuropsychologia.2005.06.011. Epub 2005 Aug 19.
Lesions of the orbital frontal lobe, particularly its medial sectors, are known to cause deficits in empathic ability, whereas the role of this region in theory of mind processing is the subject of some controversy. In a functional magnetic resonance imaging study with healthy participants, emotional perspective-taking was contrasted with cognitive perspective-taking in order to examine the role of the orbital frontal lobe in subcomponents of theory of mind processing. Subjects responded to a series of scenarios presented visually in three conditions: emotional perspective-taking, cognitive perspective-taking and a control condition that required inferential reasoning, but not perspective-taking. Group results demonstrated that the medial orbitofrontal lobe, defined as Brodmann's areas 11 and 25, was preferentially involved in emotional as compared to cognitive perspective-taking. This finding is both consistent with the lesion literature, and resolves the inconsistency of orbital frontal findings in the theory of mind literature.
已知眶额叶，尤其是其内侧部分的损伤会导致共情能力缺陷，而该区域在心理理论加工中的作用存在一定争议。在一项针对健康参与者的功能磁共振成像研究中，将情感观点采择与认知观点采择进行对比，以检验眶额叶在心理理论加工子成分中的作用。受试者在三种条件下对一系列视觉呈现的情景做出反应：情感观点采择、认知观点采择以及一个需要推理但不需要观点采择的对照条件。组间结果表明，定义为布罗德曼区11和25的内侧眶额叶在情感观点采择中比在认知观点采择中更易被激活。这一发现既与损伤研究文献一致，也解决了心理理论文献中眶额叶研究结果的不一致性。
