Pallanti Stefano, Lotti Torello, Urpe Mauro
Institute of Neuroscience, University of Florence, Florence, Italy.
Dermatol Clin. 2005 Oct;23(4):695-701. doi: 10.1016/j.det.2005.05.019.
Atopic dermatitis is a pruritic skin disease affecting predominantly young people. There is evidence that psychologic stress constitutes an increased risk for atopy and influences the disease's clinical course. This risk is believed mediated by the effects of stress on neuroimmunoregulation, which in turn modulates the hypersensitivity response and involves immunoglobulin E-mediated inflammation, helper T-cell 2 predominance, and eosinophilia. This article examines theoretic perspectives and other behavioral dimensions, such as maternal caring behavior, infant response to stress, temperament, and the so-called "hygiene hypothesis." The Darwinian framework and the mental scenario are examined. These processes may be akin to the generation of antibodies by the immune system.
特应性皮炎是一种主要影响年轻人的瘙痒性皮肤病。有证据表明，心理压力会增加患特应性疾病的风险，并影响该疾病的临床病程。人们认为这种风险是由压力对神经免疫调节的影响介导的，而神经免疫调节反过来又会调节超敏反应，涉及免疫球蛋白E介导的炎症、辅助性T细胞2优势以及嗜酸性粒细胞增多。本文探讨了理论观点以及其他行为维度，如母亲的关爱行为、婴儿对压力的反应、气质以及所谓的“卫生假说”。同时审视了达尔文主义框架和心理情境。这些过程可能类似于免疫系统产生抗体的过程。
