Nesbitt R U, Sandmann B J
J Pharm Sci. 1977 Apr;66(4):519-22. doi: 10.1002/jps.2600660414.
The solubility of silver sulfadiazine as a function of pH was determined in nitric acid-potassium nitrate buffer for pH 2-3 and in 2-(N-morpholino)ethanesulfonic acid buffer for pH 6-7. As the salt of a weak organic acid, silver sulfadiazine exhibits the anticipated increase in solubility with an increasing hydrogen-ion concentration. Measurement of the silver-ion concentration was carried out using a silver-ion selective electrode. The methods of known subtraction and known addition were utilized to measure the total concentration of the silver ion in solution. Evidence was obtained to indicate that the salt is completely ionized in aqueous solution.
在pH值为2 - 3的硝酸 - 硝酸钾缓冲液以及pH值为6 - 7的2 -（N - 吗啉代）乙磺酸缓冲液中测定了磺胺嘧啶银的溶解度随pH值的变化情况。作为一种弱有机酸的盐，磺胺嘧啶银随着氢离子浓度的增加，溶解度呈现出预期的增加。使用银离子选择性电极测量银离子浓度。采用已知减量法和已知增量法来测量溶液中银离子的总浓度。有证据表明该盐在水溶液中完全电离。
