Nesbitt R U, Sandmann B J
J Pharm Sci. 1978 Jul;67(7):1012-7. doi: 10.1002/jps.2600670739.
The solubilities of silver sulfapyridine, silver sulfamethazine, and silver sulfamethizole as a function of pH were determined in nitric acid-potassium nitrate, acetate, and sulfonic acid buffers. All silver sulfonamides showed an increase in solubility with increasing hydrogen-ion concentration, a behavior which closely paralleled the protonation of the p-amino function of the sulfonamide. A silver-ion selective electrode was used to measure silver-ion concentration in solution and the methods of known subtraction and known addition were used to measure total silver. Both silver sulfamethizole and silver sulfamethazine were ionized completely in solution. Silver sulfapyridine was ionized completely only in the more acidic pH 2-3 range. A comparison of the physical properties of the silver salts for which mortality studies were available revealed a unique set of properties for silver sulfadiazine.
在硝酸 - 硝酸钾、乙酸盐和磺酸盐缓冲液中测定了磺胺吡啶银、磺胺二甲嘧啶银和磺胺甲噻二唑银的溶解度随pH的变化。所有磺胺银盐的溶解度都随氢离子浓度的增加而增加，这种行为与磺胺酰胺对氨基官能团的质子化密切平行。使用银离子选择性电极测量溶液中的银离子浓度，并使用已知减量法和已知增量法测量总银量。磺胺甲噻二唑银和磺胺二甲嘧啶银在溶液中完全电离。磺胺吡啶银仅在酸性更强的pH 2 - 3范围内完全电离。对已有死亡率研究的银盐物理性质进行比较，发现磺胺嘧啶银具有一组独特的性质。
