Toll样受体4在对霍乱弧菌O1 El tor菌株（缺乏霍乱毒素和辅助毒素产生）的促炎反应中的作用
Role of toll-like receptor 4 in the proinflammatory response to Vibrio cholerae O1 El tor strains deficient in production of cholera toxin and accessory toxins.
作者信息
Haines G Kenneth, Sayed Blayne Amir, Rohrer Melissa S, Olivier Verena, Satchell Karla J Fullner
机构信息
Northwestern University, Dept. of Microbiology-Immunology, 303 E. Chicago Avenue, Tarry 3-713, Chicago, IL 60611, USA.
出版信息
Infect Immun. 2005 Sep;73(9):6157-64. doi: 10.1128/IAI.73.9.6157-6164.2005.
Abstract
Following intranasal inoculation, Vibrio cholerae KFV101 (DeltactxAB DeltahapA DeltahlyA DeltartxA) colonizes and stimulates tumor necrosis factor alpha and interleukin 1beta (IL-1beta) in mice, similar to what occurs with isogenic strain P4 (DeltactxAB), but is less virulent and stimulates reduced levels of IL-6, demonstrating a role for accessory toxins in pathogenesis. Morbidity is enhanced in C3H/HeJ mice, indicating that Toll-like receptor 4 is important for infection containment.
摘要
经鼻内接种后，霍乱弧菌KFV101（ΔctxAB ΔhapA ΔhlyA ΔrtxA）在小鼠体内定殖并刺激肿瘤坏死因子α和白细胞介素1β（IL-1β），这与同基因菌株P4（ΔctxAB）的情况相似，但毒力较低，刺激产生的IL-6水平降低，表明辅助毒素在发病机制中起作用。C3H/HeJ小鼠的发病率增加，表明Toll样受体4对感染控制很重要。
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