Hatton G I, Yang Q Z, Koran L E
Neuroscience Program, Michigan State University, East Lansing 48824-1117.
Brain Res. 1992 Feb 14;572(1-2):291-5. doi: 10.1016/0006-8993(92)90487-t.
Among magnocellular neurosecretory neurons (MNCs), the frequency of dye coupling, and thus also of electrotonic coupling, is reduced in male rats following castration. Testosterone replacement prevented this reduction suggesting a modulatory role for gonadal steroids. To determine whether gonadal steroids in females influenced coupling incidence, Lucifer yellow CH injections were made in MNCs in slices taken from ovariectomized rats, either untreated or implanted with capsules containing estradiol-17 beta or estradiol-17 alpha, or from sham operated rats. In groups without biologically active estradiol, incidence of dye coupling was increased by 138-169% over those with normal plasma levels, as measured by radioimmunoassay. We conclude that estradiol and testosterone have opposite effects on coupling frequency among MNCs and that the facilitatory effects of testosterone in males are unlikely to be via its aromatization to estrogen.
在大细胞神经分泌神经元（MNCs）中，去势后的雄性大鼠染料偶联频率以及电紧张偶联频率降低。睾酮替代可防止这种降低，表明性腺类固醇具有调节作用。为了确定雌性动物中的性腺类固醇是否影响偶联发生率，对取自未处理或植入含17β - 雌二醇或17α - 雌二醇胶囊的去卵巢大鼠或假手术大鼠的脑片MNCs进行了路西法黄CH注射。在没有生物活性雌二醇的组中，通过放射免疫测定，染料偶联发生率比血浆水平正常的组增加了138 - 169%。我们得出结论，雌二醇和睾酮对MNCs中的偶联频率具有相反的作用，并且雄性动物中睾酮的促进作用不太可能是通过其芳香化转化为雌激素实现的。
