Xie Jing-tian, Wang Chong-zhi, Wang An-bao, Wu Jian, Basila Daniel, Yuan Chun-su
Tang Center for Herbal Medicine Research;the Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA.
Acta Pharmacol Sin. 2005 Sep;26(9):1104-10. doi: 10.1111/j.1745-7254.2005.00156.x.
The antihyperglycemic effects of the total ginsenosides in Chinese ginseng (TGCG), extracted from leaves and the stem, were evaluated in diabetic C57BL/6J ob/ob mice.
Animals received daily intraperitoneal injections of TGCG (100 and 200 mg/kg) or oral administration (150 and 300 mg/kg) for 12 d. Fasting blood glucose levels and body weight were measured after fasting the animals for 4 h. Peripheral glucose use was also measured using an intraperitoneal glucose tolerance test.
In the injection group, a high dose of TGCG (200 mg/kg) significantly lowered the fasting blood glucose levels in ob/ob mice on d 12 (153+/-16 mg/dL vs 203+/-9.8 mg/dL, P<0.01, compared to vehicle-treated group). In the oral group, blood glucose decreased notably with a dose of TGCG (300 mg/kg) on d 12 (169.1+/-12.6 mg/dL vs 211.6+/-13.8 mg/dL, P<0.05, compared to the vehicle-treated group). Glucose tolerance was also improved markedly in ob/ob mice. Furthermore, a significant reduction in bodyweight (P<0.05) was observed after 12 d of TGCG (300 mg/kg) treatment in mice from the oral group.
The results indicated that in a diabetic ob/ob mouse model TGCG was endowed with significant anti-hyperglycemic and anti-obesity properties. Therefore, the total ginsenosides extracted from Chinese ginseng leaves and the stem may have some potential for treating diabetes.
评估从人参叶和茎中提取的人参总皂苷（TGCG）对糖尿病C57BL/6J ob/ob小鼠的降血糖作用。
动物每天腹腔注射TGCG（100和200 mg/kg）或口服给药（150和300 mg/kg），持续12天。禁食4小时后测量空腹血糖水平和体重。还通过腹腔葡萄糖耐量试验测量外周葡萄糖利用情况。
在注射组中，高剂量的TGCG（200 mg/kg）在第12天显著降低了ob/ob小鼠的空腹血糖水平（153±16 mg/dL对203±9.8 mg/dL，与溶剂处理组相比，P<0.01）。在口服组中，第12天给予剂量为TGCG（300 mg/kg）时血糖显著降低（169.1±12.6 mg/dL对211.6±13.8 mg/dL，与溶剂处理组相比，P<0.05）。ob/ob小鼠的葡萄糖耐量也明显改善。此外，口服组小鼠在接受TGCG（300 mg/kg）治疗12天后体重显著降低（P<0.05）。
结果表明，在糖尿病ob/ob小鼠模型中，TGCG具有显著的降血糖和抗肥胖特性。因此，从人参叶和茎中提取的总皂苷可能具有治疗糖尿病的潜力。
