Bozaci Elif Aylin, Taşkin Salih, Gürkan Ozlem, Atasoy Cetin, Ersoy Zinet Gül, Erekul Selim, Numanoğlu Numan, Ortaç Firat
Ankara University, Medical Faculty Department of Obstetrics and Gynecology, Gezegen S. No: 7/4, Büyükesat, Ankara, Turkey.
Gynecol Oncol. 2005 Dec;99(3):753-6. doi: 10.1016/j.ygyno.2005.07.012. Epub 2005 Aug 22.
Choriocarcinoma mostly metastasizes to lung parenchyma. Its pulmonary tumor embolism and cardiac metastasis are very rarely encountered, of which antemortem diagnosis is even more rare.
To our knowledge, we present the first case of intracavitary cardiac metastasis and pulmonary tumor emboli of choriocarcinoma diagnosed and treated without any surgical intervention. Multi-agent chemotherapy led to almost complete regression of cardiac and pulmonary lesions and normalization of beta-hCG levels.
Cardiac metastasis of choriocarcinoma must be kept in mind for cases of cardiac mass in reproductive age women, especially when history and clinical presentation are suggestive for gestational trophoblastic disease. As the tumor is highly sensitive, chemotherapy together with biochemical and radiological monitoring constitutes an effective treatment modality if cardiopulmonary functions are not deteriorating.
绒毛膜癌大多转移至肺实质。其肺肿瘤栓塞和心脏转移非常罕见,其中生前诊断更为罕见。
据我们所知,我们报告了首例绒毛膜癌腔内心脏转移和肺肿瘤栓塞病例,该病例未经任何手术干预即得到诊断和治疗。多药化疗使心脏和肺部病变几乎完全消退,β - 人绒毛膜促性腺激素水平恢复正常。
对于育龄期女性心脏肿块病例,尤其是病史和临床表现提示为妊娠滋养细胞疾病时,必须考虑绒毛膜癌心脏转移的可能性。由于该肿瘤高度敏感,如果心肺功能未恶化,化疗联合生化及影像学监测构成一种有效的治疗方式。