Shirane R, Sato S, Sato K, Kameyama M, Ogawa A, Yoshimoto T, Hatazawa J, Ito M
Division of Neurosurgery, Tohoku University, Sendai City, Japan.
Childs Nerv Syst. 1992 May;8(3):118-23. doi: 10.1007/BF00298263.
In this study, regional cerebral blood flow (rCBF) and the cerebral metabolic rate of oxygen (rCMRO2) were measured using positron emission tomography (PET) with oxygen-15 radiopharmaceuticals to clarify the pathophysiology of ventriculomegaly in the developing brain. Four hydrocephalic infants without severe neurological deficit were studied. Hypoperfusion was observed in the frontal, parietal, and visual association cortices which surrounded dilated anterior or posterior horns of the lateral ventricle. Lower rCMRO2 values than adult rates were observed in all cases. In the infants with markedly enlarged anterior or posterior horns, the surrounding cortices showed relatively lower rCMRO2 values with the fall of rCBF. Postoperative studies were performed in two infants. rCMRO2 increased in every region after ventriculoperitoneal shunting, but little change was observed in rCBF. These results indicate that metabolic deterioration occurs in the developing brain with hydrocephalus.
在本研究中，使用氧-15放射性药物的正电子发射断层扫描（PET）测量局部脑血流量（rCBF）和脑氧代谢率（rCMRO2），以阐明发育中大脑脑室扩大的病理生理学。对4名无严重神经功能缺损的脑积水婴儿进行了研究。在围绕侧脑室扩张的前角或后角的额叶、顶叶和视觉联合皮质中观察到灌注不足。所有病例的rCMRO2值均低于成人水平。在前角或后角明显增大的婴儿中，随着rCBF下降，周围皮质的rCMRO2值相对较低。对两名婴儿进行了术后研究。脑室腹腔分流术后每个区域的rCMRO2均升高，但rCBF变化不大。这些结果表明，脑积水患儿发育中的大脑会出现代谢恶化。
