Cambar J, Saurel J, Canellas J
C R Seances Soc Biol Fil. 1979;173(5):904-9.
After confirmation of the intense and very fast myorelaxant effect of theophylline on isolated glomeruli, xanthic reagent myotoxic effects are shown during more or less long contacts with these glomerular suspensions. We studied isolated glomeruli diameter evolution according to reagent dose (0,25 to 10 mg/ml) and its contact length (1, 5, 10 minutes). If the diameter remains practically constant during all the period for the lowest doses, it begins to decrease after the 5th minute for higher (1 and 2,5 mg/ml) and cracks up in the first minutes for the biggest ones (5 and 10 mg/ml). Pharmacologic and toxic actions are discussed ; hypothesis of a toxic effect at smooth muscular cells level is proposed.
在证实茶碱对分离的肾小球有强烈且非常快速的肌松作用后，在与这些肾小球悬液进行或多或少较长时间接触时，显示出黄嘌呤试剂的肌毒性作用。我们根据试剂剂量（0.25至10毫克/毫升）及其接触时间（1、5、10分钟）研究了分离的肾小球直径的变化。对于最低剂量，在整个时间段内直径实际上保持恒定；对于较高剂量（1和2.5毫克/毫升），在第5分钟后开始减小；对于最大剂量（5和10毫克/毫升），在最初几分钟内就出现破裂。文中讨论了药理和毒性作用；提出了在平滑肌细胞水平产生毒性作用的假说。
