Cambar J, Saurel J, Canellas J
Eur J Pharmacol. 1978 May 15;49(2):193-6. doi: 10.1016/0014-2999(78)90078-x.
Theophylline, infused i.v. into rats increased the diameter of the glomerular afferent arterioles by 35.78%; when added to a suspension of isolated glomeruli, it increased the diameter of the capillary tuft within the glomerulus by 25-30%. These variations in diameter can be explained by the myorelaxant effect of theophylline on the smooth contractile fibers present in the arteriolar cells and in certain glomerular cells, such as the mesangial cells. These observations explain, in part, the marked changes in glomerular hemodynamics caused by the injection of theophylline.
静脉注射到大鼠体内的茶碱使肾小球入球小动脉直径增加了35.78%；当添加到分离的肾小球悬液中时，它使肾小球内毛细血管袢的直径增加了25% - 30%。直径的这些变化可以用茶碱对存在于小动脉细胞和某些肾小球细胞（如系膜细胞）中的平滑肌收缩纤维的肌松弛作用来解释。这些观察结果部分解释了注射茶碱引起的肾小球血流动力学的显著变化。
