Dunn F L
Duke University Medical Center, Durham, North Carolina.
Endocrinol Metab Clin North Am. 1992 Jun;21(2):395-414.
Accelerated atherosclerosis is a major complication of long-term diabetes mellitus, and this is partly due to associated abnormalities of lipoprotein metabolism. Hypertriglyceridemia is usually due to poorly controlled diabetes and responds to improved glucose control. Hypercholesterolemia is usually not related to poor diabetic control and should be treated with a cholesterol lowering diet and drugs according to the National Cholesterol Education Program guidelines. Low HDL-C is common in NIDDM and does not fully return to normal with improved diabetic control. Dyslipidemia in diabetics should be aggressively identified and treated to decrease cardiovascular risk.
加速动脉粥样硬化是长期糖尿病的主要并发症，部分原因是脂蛋白代谢相关异常。高甘油三酯血症通常归因于糖尿病控制不佳，血糖控制改善后可缓解。高胆固醇血症通常与糖尿病控制不佳无关，应根据美国国家胆固醇教育计划指南采用降胆固醇饮食和药物治疗。低高密度脂蛋白胆固醇在非胰岛素依赖型糖尿病中很常见，即使糖尿病控制改善也不会完全恢复正常。糖尿病患者的血脂异常应积极识别并治疗，以降低心血管风险。
