Khademi Farzad, Faghri Jamshid, Poursina Farkhondeh, Esfahani Bahram Nasr, Moghim Sharareh, Fazeli Hossein, Adibi Peyman, Mirzaei Nasrin, Akbari Mojtaba, Safaei Hajieh Ghasemian
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Gastroenterology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2013 Dec;18(12):1056-60.
Helicobacter pylori (H. pylori) resistance to antibiotics has become a global problem and is an important factor in determining the outcome of treatment of infected patients. The purpose of this study was to determine the H. pylori resistance to clarithromycin, metronidazole, and amoxicillin in gastrointestinal disorders patients.
In this study, a total of 260 gastric antrum biopsy specimens were collected from patients with gastrointestinal disorders who referred to Endoscopy Section of the Isfahan Hospitals. The E-test and Modified Disk Diffusion Method (MDDM) were used to verify the prevalence of antibiotic resistance in 78 H. pylori isolates to the clarithromycin, metronidazole, and amoxicillin.
H. pylori resistance to clarithromycin, metronidazole, and amoxicillin were 15.3, 55.1, and 6.4%, respectively. In this study, we had one multidrug resistance (MDR) isolates from patient with gastritis and peptic ulcer disease.
Information on antibiotic susceptibility profile plays an important role in empiric antibiotic treatment and management of refractive cases. According to the results obtained in this study, H. pylori resistance to clarithromycin and metronidazole was relatively high. MDR strains are emerging and will have an effect on the combination therapy.
幽门螺杆菌（H. pylori）对抗生素的耐药性已成为全球性问题，并且是决定感染患者治疗结果的重要因素。本研究的目的是确定胃肠道疾病患者中幽门螺杆菌对克拉霉素、甲硝唑和阿莫西林的耐药情况。
在本研究中，共收集了260份来自转诊至伊斯法罕医院内镜科的胃肠道疾病患者的胃窦活检标本。采用E-test和改良纸片扩散法（MDDM）来验证78株幽门螺杆菌分离株对克拉霉素、甲硝唑和阿莫西林的抗生素耐药率。
幽门螺杆菌对克拉霉素、甲硝唑和阿莫西林的耐药率分别为15.3%、55.1%和6.4%。在本研究中，我们从一名患有胃炎和消化性溃疡疾病的患者中分离出一株多重耐药（MDR）菌株。
抗生素敏感性谱信息在经验性抗生素治疗和难治性病例的管理中起着重要作用。根据本研究获得的结果，幽门螺杆菌对克拉霉素和甲硝唑的耐药性相对较高。多重耐药菌株正在出现，并将对联合治疗产生影响。
