Khanna S C, Garg S K, Sharma S P
Department of Molecular Biology, Guru Nanak Dev University, Amritsar, India.
Gerontology. 1992;38(1-2):9-12. doi: 10.1159/000213301.
The glutathione reductase activity was estimated in brain and liver of male mice of different age groups fed on butylated hydroxy anisole (BHA), propyl gallate (PG) and alpha-tocopherol (TP). A significant increase in glutathione reductase activity was observed with TP during all the phases (pre-reproductive, reproductive and post-reproductive). Antioxidants enhanced the enzyme activity in both the tissues with the exception of BHA in brain during reproductive and PG in liver during pre-reproductive phases respectively. The enhanced reducing potential of the cell in terms of added bioconversion of GSSG to GSH may account for increase in longevity on antioxidant treatment.
在以丁基羟基茴香醚（BHA）、没食子酸丙酯（PG）和α-生育酚（TP）喂养的不同年龄组雄性小鼠的脑和肝脏中测定了谷胱甘肽还原酶活性。在所有阶段（生殖前期、生殖期和生殖后期），TP均使谷胱甘肽还原酶活性显著增加。抗氧化剂增强了两个组织中的酶活性，但在生殖期脑内的BHA和生殖前期肝脏内的PG除外。就增加的GSSG向GSH生物转化而言，细胞增强的还原电位可能是抗氧化剂治疗后寿命延长的原因。
