抗氧化剂对两性霉素B生物活性的影响。
Influence of antioxidants on the bioactivity of amphotericin B.
作者信息
Andrews F A, Beggs W H, Sarosi G A
出版信息
Antimicrob Agents Chemother. 1977 Apr;11(4):615-8. doi: 10.1128/AAC.11.4.615.
Abstract
Four antioxidants, propyl gallate, butylated hydroxyanisole, butylated hydroxytoluene, and d-alpha-tocopherol acid succinate were found to stabilize amphotericin B and to prolong its antifungal activity against Candida albicans. Although each of the antioxidants was effective in this respect, propyl gallate and butylated hydroxyanisole were better than butylated hydroxytoluene and d-alpha-tocopherol acid succinate. None of the antioxidants alone adversely affected normal cell growth. It is suggested that amphotericin B instability is due, at least in part, to lability of the carbon-carbon double bonds of the polyene moiety toward autoxidation. By protecting the drug molecule with an antioxidant, it is possible to significantly lower the quantity of AB necessary to obtain particular antifungal effects.
摘要
发现四种抗氧化剂，没食子酸丙酯、丁基羟基茴香醚、二丁基羟基甲苯和琥珀酸维生素E，能稳定两性霉素B，并延长其对白色念珠菌的抗真菌活性。尽管每种抗氧化剂在这方面都有效，但没食子酸丙酯和丁基羟基茴香醚比二丁基羟基甲苯和琥珀酸维生素E更好。单独使用这些抗氧化剂均不会对正常细胞生长产生不利影响。提示两性霉素B的不稳定性至少部分归因于多烯部分碳-碳双键对自动氧化的不稳定性。通过用抗氧化剂保护药物分子，可以显著降低获得特定抗真菌效果所需的两性霉素B的用量。
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