来自假乌檀叶古柯树皮的甲基吡咯托烷生物碱。
Methylpyrrole tropane alkaloids from the bark of Erythroxylum vacciniifolium.
作者信息
Zanolari Boris, Guilet David, Marston Andrew, Queiroz Emerson F, Paulo Marçal de Queiroz, Hostettmann Kurt
机构信息
Laboratory of Pharmacognosy and Phytochemistry, University of Geneva, CH-1211 Geneva 4, Switzerland.
出版信息
J Nat Prod. 2005 Aug;68(8):1153-8. doi: 10.1021/np040144h.
Nine new tropane alkaloids substituted by a methylpyrrole moiety were isolated from the bark of Erythroxylum vacciniifolium, a Brazilian endemic plant used in traditional medicine and locally known as catuaba. All compounds were elucidated as tropanediol or -triol alkaloids esterified by at least one 1-methyl-1H-pyrrole-2-carboxylic acid. One of the isolated compounds was identified as a tropane alkaloid N-oxide. Their structures were determined by high-resolution mass spectrometry and multidimensional NMR spectroscopy.
从巴西本土植物红古豆（Erythroxylum vacciniifolium）的树皮中分离出九种新的由甲基吡咯部分取代的托烷生物碱，这种植物在传统医学中使用，当地称为卡图巴。所有化合物均被鉴定为托烷二醇或 - 三醇生物碱，至少被一个1 - 甲基 - 1H - 吡咯 - 2 - 羧酸酯化。分离出的一种化合物被鉴定为托烷生物碱N - 氧化物。它们的结构通过高分辨率质谱和多维核磁共振光谱确定。
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