从茄科假麻黄树（Erythroxylum vacciniifolium Mart.）树皮中分离得到的两种新托烷生物碱。

Two new tropane alkaloids from the bark of Erythroxylum vacciniifolium Mart. (Erythroxylaceae).

作者信息

Queiroz Emerson F, Zanolari Boris, Marston Andrew, Guilet David, Burgener Leila, Paulo Marçal de Queiroz, Hostettmann Kurt

机构信息

Department of Research and Development, Aché Laboratórios Farmacêuticos S.A. Rodovia Presidente Dutra, km 222,2. Guarulhos-SP, cep 07034-904, Brazil.

出版信息

Nat Prod Commun. 2009 Oct;4(10):1337-40.

PMID:19911567

Abstract

Two new tropane alkaloid N-oxides substituted by a methylpyrrole moiety were isolated from the bark of Erythroxylum vacciniifolium Mart. (Erythroxylaceae), a Brazilian indigenous plant, locally known as catuaba and used in traditional medicine as an aphrodisiac. The alkaloid structures were determined by a combination of high resolution mass spectrometry and multi-dimensional NMR spectroscopy.

摘要

从巴西本土植物红古豆（Erythroxylum vacciniifolium Mart.，古柯科）的树皮中分离出了两种新的由甲基吡咯部分取代的托烷生物碱N-氧化物。这种植物在当地被称为卡图巴，在传统医学中用作壮阳药。通过高分辨率质谱和多维核磁共振光谱相结合的方法确定了生物碱的结构。