山药地上部分化合物的神经保护和抗氧化活性

Neuroprotective and antioxidant activity of compounds from the aerial parts of Dioscorea opposita.

作者信息

Ma Chao, Wang Wei, Chen Yun-Yun, Liu Rui-Ning, Wang Ru-Feng, Du Li-Jun

机构信息

Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, People's Republic of China.

出版信息

J Nat Prod. 2005 Aug;68(8):1259-61. doi: 10.1021/np050021c.

DOI:10.1021/np050021c

PMID:16124773

Abstract

Bioactivity-guided fractionation of an ethanol extract of the aerial parts of Dioscorea opposita afforded a new compound, 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione (1), and four known compounds, chrysoeriol 4'-O-beta-D-glucopyranoside (2), chrysoeriol 7-O-beta-D-glucopyranoside (3), alternanthin (4), and daucosterol. The structure of 1 was established on the basis of the interpretation of its 1D and 2D NMR spectrascopic data. Compounds 1-4 exhibited both promising neuroprotective effects and discernible to moderate antioxidant activities in vitro.

摘要

对山药地上部分乙醇提取物进行生物活性导向分离，得到一种新化合物6,7 - 二羟基 - 2 - 甲氧基 - 1,4 - 菲醌（1）以及四种已知化合物，芹菜素4'-O-β-D-吡喃葡萄糖苷（2）、芹菜素7 - O-β-D-吡喃葡萄糖苷（3）、互生红菌素（4）和胡萝卜苷。通过对其一维和二维核磁共振光谱数据的解析确定了1的结构。化合物1 - 4在体外均表现出有前景的神经保护作用和明显至中等程度的抗氧化活性。