HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany ; ICBAS, University of Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal.
Evid Based Complement Alternat Med. 2013;2013:423713. doi: 10.1155/2013/423713. Epub 2013 Jul 31.
Chemotherapy-induced neuropathy (CIPN) has a relevant impact on the quality of life of cancer patients. There are no curative conventional treatments, so further options have to be investigated. We conducted a systematic review in English and Chinese language databases to illuminate the role of medical herbs. 26 relevant studies on 5 single herbs, one extract, one receptor-agonist, and 8 combinations of herbs were identified focusing on the single herbs Acorus calamus rhizoma, Cannabis sativa fructus, Chamomilla matricaria, Ginkgo biloba, Salvia officinalis, Sweet bee venom, Fritillaria cirrhosae bulbus, and the herbal combinations Bu Yang Huan Wu, modified Bu Yang Huan Wu plus Liuwei Di Huang, modified Chai Hu Long Gu Mu Li Wan, Geranii herba plus Aconiti lateralis praeparata radix , Niu Che Sen Qi Wan (Goshajinkigan), Gui Zhi Jia Shu Fu Tang (Keishikajutsubuto), Huang Qi Wu Wu Tang (Ogikeishigomotsuto), and Shao Yao Gan Cao Tang (Shakuyakukanzoto). The knowledge of mechanism of action is still limited, the quality of clinical trials needs further improvement, and studies have not yielded enough evidence to establish a standard practice, but a lot of promising substances have been identified. While CIPN has multiple mechanisms of neuronal degeneration, a combination of herbs or substances might deal with multiple targets for the aim of neuroprotection or neuroregeneration in CIPN.
化疗诱导的周围神经病变（CIPN）对癌症患者的生活质量有重要影响。目前尚无有效的常规治疗方法，因此需要进一步研究其他治疗方法。我们在英文和中文数据库中进行了系统评价，以阐明草药的作用。共确定了 26 项关于 5 种单味草药、1 种提取物、1 种受体激动剂和 8 种草药组合的相关研究，这些研究主要关注单味草药石菖蒲、大麻籽、洋甘菊、银杏叶、鼠尾草、甜蜂毒、浙贝母和草药组合补阳还五汤、改良补阳还五汤加六味地黄丸、改良柴胡龙骨牡蛎丸、当归四逆汤加附子、牛蒡子散（葛根汤）、桂枝加芍药生姜各一两人参三两新加汤（桂芍知母汤）、黄芪五物汤（芍药甘草汤）和芍药甘草汤。作用机制的知识仍然有限，临床试验的质量需要进一步提高，而且研究还没有提供足够的证据来建立标准的治疗方法，但已经确定了许多有前途的物质。虽然 CIPN 有多种神经元退化的机制，但草药或物质的组合可能针对 CIPN 中的多个靶点，起到神经保护或神经再生的作用。
