James D R, Owen G, Campbell I A, Goodchild M C
Department of Medical Biochemistry, University Hospital of Wales, Cardiff.
Gut. 1992 May;33(5):707-10. doi: 10.1136/gut.33.5.707.
Vitamin A status was examined in nine adult cystic fibrosis patients and six adult control subjects, together with an assessment of their ability to absorb 10,000 IU of retinyl palmitate from a test meal, taken with appropriate pancreatic enzyme supplements. Median baseline values for plasma retinol and carotene, as well as median serum retinol binding protein concentrations, were significantly lower in cystic fibrosis patients than in control subjects. One cystic fibrosis patient had a raised fasting plasma retinyl ester concentration suggestive of chronic hypervitaminosis A, but no symptoms of toxicity. Measures of vitamin A absorption were also significantly lower in cystic fibrosis patients, although there was considerable overlap with control values. No correlation was observed between measures of baseline status and vitamin A absorption. Measurement of plasma retinyl esters may be an appropriate investigation in those patients considered to be at risk of chronic hypervitaminosis A.
对9名成年囊性纤维化患者和6名成年对照者的维生素A状况进行了检查，同时评估了他们在服用适当胰酶补充剂的情况下，从测试餐中吸收10,000 IU棕榈酸视黄酯的能力。囊性纤维化患者的血浆视黄醇和胡萝卜素的基线中位数以及血清视黄醇结合蛋白浓度中位数均显著低于对照者。一名囊性纤维化患者空腹血浆视黄酯浓度升高，提示慢性维生素A过多，但无中毒症状。囊性纤维化患者的维生素A吸收指标也显著较低，尽管与对照值有相当大的重叠。基线状况指标与维生素A吸收之间未观察到相关性。对于那些被认为有慢性维生素A过多风险的患者，检测血浆视黄酯可能是一项合适的检查。
