Chilton Beverly S, Hewetson Aveline
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA.
Curr Top Dev Biol. 2005;68:1-23. doi: 10.1016/S0070-2153(05)68001-5.
Prolactin (PRL) and growth hormone (GH) act by way of their receptors as either hormones (systemically) or cytokines (locally). The Jak2/Stat5 pathway is the principal route by which PRL/GH activate target genes. The availability of knockout mice for each member of this signaling cascade has provided opportunities to understand their unique interactions. Jak2 is important in alternative signal transduction schema such as the MAP kinase and PI3K/Akt pathways. The putative Jak2/RUSH pathway is based on the fact that RUSH mediates the ability of PRL to augment progesterone-dependent gene transcription. New evidence shows that suppressors, regulators, and degraders control Jak2/Stat5. This review focuses on the most recent advances in the field of PRL/GH signal transduction.
催乳素（PRL）和生长激素（GH）通过其受体发挥作用，既作为激素（全身性地），也作为细胞因子（局部地）。Jak2/Stat5途径是PRL/GH激活靶基因的主要途径。该信号级联反应中每个成员的基因敲除小鼠的可得性为理解它们独特的相互作用提供了机会。Jak2在诸如MAP激酶和PI3K/Akt途径等替代信号转导模式中很重要。推测的Jak2/RUSH途径基于RUSH介导PRL增强孕酮依赖性基因转录的能力这一事实。新证据表明，抑制因子、调节因子和降解因子控制着Jak2/Stat5。本综述聚焦于PRL/GH信号转导领域的最新进展。
