综述：催乳素对成体干细胞的调控
Minireview: prolactin regulation of adult stem cells.
作者信息
Sackmann-Sala Lucila, Guidotti Jacques-Emmanuel, Goffin Vincent
机构信息
Institut Necker Enfants Malades, Inserm Unité1151, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8253, Team Prolactin/Growth Hormone Pathophysiology, Faculty of Medicine, University Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.
出版信息
Mol Endocrinol. 2015 May;29(5):667-81. doi: 10.1210/me.2015-1022. Epub 2015 Mar 20.
Abstract
Adult stem/progenitor cells are found in many tissues, where their primary role is to maintain homeostasis. Recent studies have evaluated the regulation of adult stem/progenitor cells by prolactin in various target tissues or cell types, including the mammary gland, the prostate, the brain, the bone marrow, the hair follicle, and colon cancer cells. Depending on the tissue, prolactin can either maintain stem cell quiescence or, in contrast, promote stem/progenitor cell expansion and push their progeny towards differentiation. In many instances, whether these effects are direct or involve paracrine regulators remains debated. This minireview aims to overview the current knowledge in the field.
摘要
成体干/祖细胞存在于许多组织中，其主要作用是维持体内稳态。最近的研究评估了催乳素在各种靶组织或细胞类型中对成体干/祖细胞的调控，这些组织或细胞类型包括乳腺、前列腺、大脑、骨髓、毛囊和结肠癌细胞。根据组织的不同，催乳素既可以维持干细胞的静止状态，或者相反，促进干/祖细胞的扩增，并促使其后代细胞分化。在许多情况下，这些作用是直接的还是涉及旁分泌调节因子仍存在争议。本综述旨在概述该领域的当前知识。
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