Schmidt M, Kołataj A, Bulla J, Król T, Witek B, Banasik A
Institute of Biology, Pedagogic University in Kielce, Poland.
Horm Metab Res. 1992 Jan;24(1):21-5. doi: 10.1055/s-2007-1003244.
Observing activity of some lysosomal enzymes in blood serum and leucocytes of rabbits subjected to injection of 200,000 units of retinol and 25 mg of hydrocortisone/kg of body weight it was found that: 1. In the effect of retinol administration there was an increase in the activity AP, BGAL, BGLU, AspAT and lipase in blood serum after 72 hours and NAGL after 168 hours while in leucocytes BGAL and NAGL after 72 hours and AGAL after 168 hours. 2. As a result of hydrocortisone injection the activity of all the enzymes examined (except Ala-Na) in blood serum increased markedly already after 24-48 hours. 3. In leucocytes hydrocortisone caused a significant increase in the activity of AP, BGRD, NAGL, BGAL, AGAL and cathepsin D. 4. The glucose level in blood plasma decreased after 48 hours and 120 hours after hydrocortisone injection and 168 hours after retinol injection.
通过观察给体重每千克注射200,000单位视黄醇和25毫克氢化可的松的兔子血清和白细胞中某些溶酶体酶的活性，发现：1. 给予视黄醇后，72小时后血清中碱性磷酸酶（AP）、β-半乳糖苷酶（BGAL）、β-葡萄糖苷酶（BGLU）、天冬氨酸氨基转移酶（AspAT）和脂肪酶活性增加，168小时后N-乙酰-β-D-氨基葡萄糖苷酶（NAGL）活性增加；而白细胞中72小时后BGAL和NAGL活性增加，168小时后α-半乳糖苷酶（AGAL）活性增加。2. 注射氢化可的松后，24至48小时后血清中所有检测酶（除丙氨酸钠外）的活性已显著增加。3. 在白细胞中，氢化可的松使AP、β-葡萄糖醛酸酶（BGRD）、NAGL、BGAL、AGAL和组织蛋白酶D的活性显著增加。4. 注射氢化可的松后48小时和120小时以及注射视黄醇后168小时，血浆葡萄糖水平下降。
