Cantani A, Micera M
Department of Pediatrics, Allergy and Clinical Immunology Division, La Sapienza University--Rome, Italy.
Eur Rev Med Pharmacol Sci. 2005 Jul-Aug;9(4):227-30.
Cow's milk (CM) allergy (CMA) is a disease of infancy, usually appearing in the first months of life. Symptoms triggered by CM at first introduction are not completely defined. The evaluation of infants for possible CMA is one of the more common problems encountered by pediatricians. Purpose of this study was to investigate the prevalence of severe reaction to CM and clinical manifestation triggered by CM administration in the nurseries.
The series includes 143 prospectively studied CM-allergic babies.
At the first introduction of CM, at the age of 1-8 months (median 4 months) all infants had immediate symptoms The babies were probably sensitized during the first days of life. Particularly sensitizing appears to be the exposure to CM formulas in the neonatal nursery.
Little doses of allergens are more sensitizing than larger ones. We provide clear evidence of the immunological effects of oral antigen administration during the neonatal period, and discuss the possible critical allergen transmission to the nursing baby via breast milk (BM).
牛奶（CM）过敏（CMA）是一种婴儿期疾病，通常出现在生命的最初几个月。首次引入CM引发的症状尚未完全明确。评估婴儿是否可能患有CMA是儿科医生遇到的较常见问题之一。本研究的目的是调查托儿所中对CM严重反应的发生率以及CM给药引发的临床表现。
该系列包括143例前瞻性研究的CM过敏婴儿。
在1至8个月龄（中位年龄4个月）首次引入CM时，所有婴儿均出现即刻症状。这些婴儿可能在生命的最初几天就已致敏。特别值得注意的是，新生儿托儿所中接触CM配方奶似乎更容易致敏。
小剂量变应原比大剂量更具致敏性。我们提供了新生儿期口服抗原给药免疫效应的明确证据，并讨论了通过母乳（BM）向哺乳婴儿传播潜在关键变应原的可能性。
