Uter W, Hegewald J, Aberer W, Ayala F, Bircher A J, Brasch J, Coenraads P-J, Schuttelaar M-L A, Elsner P, Fartasch M, Mahler V, Belloni Fortina A, Frosch P J, Fuchs T, Johansen J D, Menné T, Jolanki R, Krêcisz B, Kiec-Swierczynska M, Larese F, Orton D, Peserico A, Rantanen T, Schnuch A
Department of Medical Informatics, Biometry & Epidemiology, University of Erlangen-Nürnberg, Erlangen, Germany.
Contact Dermatitis. 2005 Sep;53(3):136-45. doi: 10.1111/j.0105-1873.2005.00673.x.
Since January 2001, the European Surveillance System on Contact Allergies (ESSCA), supported by European Union funding (contract QLK4-CT-2001-00343), has started to collect patch-test data. This comprises a standardized clinical history and the patch-test results using the European standard series, from 17 centres in 9 European countries listed above. In 2002 and 2003, 10 511 patients' test results have been pooled and analysed. The anamnestic data partly reflect the subspecialties of some centres. The most common allergen was nickel sulfate (17.3%); however, large international variations were observed. The prevalence of contact allergy to Myroxylon pereirae resin (balsam of Peru) (5.8%) is coming close to the frequency found with the fragrance mix (6.4%). Regarding contact allergy to chromium compounds, different frequencies were noted in the 2 centres focused on occupational dermatitis (2.3% in the FIOH versus 7.4% in the Nofer Institute). These most likely reflect the beneficial effect of addition of ferrous sulfate in one, but not the other country. As differences may partly be due to different patch-test reading, standardization may need to be refined further. By providing post-marketing surveillance in the field of contact allergy, ESSCA will meet its objective of increased consumer safety across Europe.
自2001年1月起，由欧盟资助（合同编号QLK4-CT-2001-00343）的欧洲接触性过敏监测系统（ESSCA）开始收集斑贴试验数据。这些数据包括标准化的临床病史以及使用欧洲标准系列进行斑贴试验的结果，数据来自上述9个欧洲国家的17个中心。在2002年和2003年，对10511例患者的试验结果进行了汇总和分析。既往病史数据部分反映了一些中心的亚专业情况。最常见的变应原是硫酸镍（17.3%）；然而，观察到较大的国际差异。对秘鲁香脂（Myroxylon pereirae树脂）的接触性过敏患病率（5.8%）已接近香料混合物的患病率（6.4%）。关于对铬化合物的接触性过敏，在专注于职业性皮炎的2个中心观察到不同的患病率（芬兰职业卫生研究所为2.3%，诺费尔研究所为7.4%）。这些很可能反映了一个国家添加硫酸亚铁而另一个国家未添加所产生的有益效果。由于差异可能部分归因于不同的斑贴试验判读，可能需要进一步完善标准化。通过在接触性过敏领域提供上市后监测，ESSCA将实现提高全欧洲消费者安全性的目标。
