Tanaka Takao, Shigeta Mari, Yamakawa Naoyuki, Usui Masahiko
Department of Ophthalmology, Kosei Chuo Hospital, Tokyo Medical University Hospital, Tokyo, Japan.
J Cataract Refract Surg. 2005 Aug;31(8):1648-51. doi: 10.1016/j.jcrs.2004.11.050.
To examine the number cells adhering to acrylic intraocular lenses (IOLs) having different degrees of surface roughness and acrylic IOLs having different contact angles.
Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan.
In this study, VA-60 CB acrylic IOLs were used. After different durations of polishing of the optics, the roughness values of the lenses were set at 10.0 nm, 2.5 nm, and 0.7 nm. Intraocular lenses were also chemically coated to achieve angles of contact of 100 degrees and 57.5 degrees, with untreated IOLs having a 93.5-degree angle of contact. Intraocular lenses were cultured for 96 hours in 1 x 10(7) spleen cells/mL of developed experimental autoimmune uveoretinitis, and the number of cells adhering to the IOLs was counted.
Fewer cells adhered to the optics of IOLs with lower roughness values, and fewer cells adhered to the IOL surface with increased contact angles.
Hydrophobic optics with small roughness values of acrylic IOLs may reduce the number of adherent cells and escaped the unexpected inflammatory cell reaction associated with intraocular inflammation in the eye.
研究附着于具有不同表面粗糙度的丙烯酸人工晶状体（IOL）以及具有不同接触角的丙烯酸IOL上的细胞数量。
日本东京医科大学医院眼科。
本研究使用VA - 60 CB丙烯酸IOL。在对光学部进行不同时长的抛光后，将镜片的粗糙度值设定为10.0纳米、2.5纳米和0.7纳米。还对人工晶状体进行化学涂层处理，以实现100度和57.5度的接触角，未处理的IOL接触角为93.5度。将人工晶状体在每毫升含1×10⁷个脾细胞的已发展的实验性自身免疫性葡萄膜视网膜炎中培养96小时，并计算附着于IOL上的细胞数量。
粗糙度值较低的IOL光学部附着的细胞较少，且随着接触角增大，IOL表面附着的细胞也较少。
丙烯酸IOL粗糙度值小的疏水光学部可能会减少附着细胞的数量，并避免与眼内炎症相关的意外炎症细胞反应。
