Ameloblastoma is a locally aggressive tumour of odontogenic origin, with an unknown aetiology. Metachronous ameloblastoma in the maxilla and the mandible is rare. In this report, a case of a 63 year-old man is described with a solid ameloblastoma in the posterior part of the upper jaw. After surgical treatment, the patient returned 8 years later with a similar lesion in the anterior lower jaw. Both ameloblastomas were of the solid type but differed in their histological patterns. No evidence of recurrence was found in either of the surgical sites for the last 4 years.