Brod B A, Rabkin M, Rhodes A R, Jegasothy B V
Department of Dermatology, University of Pittsburgh School of Medicine, Pa.
J Am Acad Dermatol. 1992 May;26(5 Pt 2):882-4. doi: 10.1016/0190-9622(92)70129-4.
A 71-year-old white woman had finely wrinkled, erythematous patches of skin that met the clinical and histologic criteria for mid-dermal elastolysis. In addition to the loss of mid-dermal elastin described in previous cases, histopathologic examination revealed a superficial and deep perivascular inflammatory infiltrate of lymphocytes and plasma cells and interstitial collections of multinucleated giant cells containing phagocytized elastin. These results support a previously postulated inflammatory pathogenesis for mid-dermal elastolysis.
一名71岁的白人女性有细小皱纹、皮肤红斑，符合真皮中层弹性组织离解的临床和组织学标准。除了先前病例中所描述的真皮中层弹性蛋白缺失外，组织病理学检查显示，浅层和深层血管周围有淋巴细胞和浆细胞炎性浸润，以及含有吞噬弹性蛋白的多核巨细胞的间质聚集。这些结果支持了先前推测的真皮中层弹性组织离解的炎症发病机制。
