Tan T, Mizobe N, Sugiyama H, Maeda Y, Naitou A, Kodera K, Sato T, Nakazawa S
Division of Neonatology, Perinatal Center, Yamanashi Prefectural Central Hospital, Yamanashi, 409-3898, Japan.
Pediatr Cardiol. 2005 Nov-Dec;26(6):801-4. doi: 10.1007/s00246-005-0947-y.
Very low-birth weight infants with patent ductus arteriosus (PDA) accompanied by severe heart failure do not respond to indomethacine therapy. It is essential to stabilize the general condition of these infants until surgical intervention. We tried to regulate the pulmonary blood flow to control congestive heart failure by administering supplemental nitrogen inhalation therapy to six very low-birth-weight infants with PDA. After the inhalation of supplemental nitrogen gas was begun, the arterial oxygen saturation and partial oxygen pressure immediately decreased. Furthermore, the blood pH, systolic pressure, and urine output significantly increased. The infants were well stabilized. Furthermore, there were no complications related to nitrogen gas inhalation. Supplemental nitrogen inhalation therapy is an effective and feasible therapy for severe congestive heart failure in very low-birth-weight infants with PDA.
患有动脉导管未闭（PDA）并伴有严重心力衰竭的极低出生体重儿对吲哚美辛治疗无反应。在进行手术干预之前，稳定这些婴儿的一般状况至关重要。我们尝试通过对六名患有PDA的极低出生体重儿进行补充氮气吸入疗法来调节肺血流量，以控制充血性心力衰竭。开始吸入补充氮气后，动脉血氧饱和度和氧分压立即下降。此外，血液pH值、收缩压和尿量显著增加。婴儿状况良好。此外，未出现与氮气吸入相关的并发症。补充氮气吸入疗法是治疗患有PDA的极低出生体重儿严重充血性心力衰竭的一种有效且可行的疗法。
